Plerixafor with and without chemotherapy in poor mobilizers: results from the German compassionate use program
نویسندگان
چکیده
منابع مشابه
Turning CD34 Non-Mobilizers into Mobilizers: A Case Report Involving Plerixafor (AMD3100).
SUMMARY: OBJECTIVE: In a significant proportion of patients with hematologic malignancies (5-30%) poor mobilization of hematopoietic stem cells (HSC) is observed. This compromises the application of effective and potentially curative high-dose chemotherapy (HDC) treatment. CASE REPORT: Here we report the case of a 38-year-old female patient who was treated for recurrent follicular B-cell non-Ho...
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چکیده ندارد.
How I treat patients who mobilize hematopoietic stem cells poorly.
Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and age are factors influencing mobilization, but genetics also contributes. Mobili...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2010
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2010.249